Oxidative damage to cells is related to aging and various clinical diseases, so it is of great significance to develop effective antioxidant drugs to reduce free radicals in the body. CD BioSciences provides comprehensive anti-oxidant peptidomimetic development services to help global customers make greater progress in preventing cellular oxidative damage and anti-aging.
Importance of Anti-oxidant Activity
When the body is subjected to harmful stimuli from the external environment, the secretion of various proteases in the body is out of control, resulting in an imbalance between reactive oxygen species (ROS) and the antioxidant defense system in the biological system, further inducing pathological changes at the cellular and tissue levels. Neurodegenerative diseases, atherosclerosis, age-related degeneration, and cancer development are all closely related to the accumulation of ROS and oxidative stress. The therapeutic effect of the antioxidant drugs currently developed for these diseases is not ideal, and the reason may be that some antioxidant drugs do not reach the relevant sites of free radical generation to play a role, especially if the mitochondria are reactive oxygen species (ROS) primary source. In addition, these drugs also have certain side effects, which are not conducive to long-term use.
Fig. 1 Formation of intracellular reactive oxygen and nitrogen species. (Szeto, 2006)
Overview of Antioxidant Peptides
Currently, many peptides and their derivatives have been shown to have antiaging, antihypertensive, neurodegenerative, and other antioxidant-mediated properties in animal experiments. For example: Szeto-Schiller (SS) peptides are antioxidant peptides containing alternating aromatic residues and basic amino acid sequences that are membrane potential independent and localize to the inner mitochondrial membrane through the plasma membrane, inhibiting mitochondrial permeability transitions and cytochrome c release, thereby preventing oxidant-induced cell death. In addition to SS peptides, several peptides consisting of electron and ROS scavengers (4-NH2-TEMPO) conjugated to XJB peptides have been used to limit oxidative stress.
Fig. 2 Accumulation and antioxidant mechanism of Szeto-Schiller-31 (SS-31) (A) and XJB-5-131 (B). (Broome, et al., 2018)
Our Services
CD BioSciences is committed to providing global customers with comprehensive development services for anti-oxidant peptidomimetics.
Using our PepDomTM platform, we can conduct targeted amino acid sequence design and unique structure and function screening according to the specific research mechanism of customers, so as to ensure that the peptidomimetics we develop have higher antioxidant activity and better transmembrane absorption effect.
Our anti-oxidant activity peptidomimetic development services include but are not limited to:
- Development of peptidomimetics for scavenging active free radicals. (e.g., ROS, RNS, MDA)
- Development of peptidomimetics that inhibit free radical producing related enzymes. (e.g., NADPH, NOX2, NOX4)
- Development of peptidomimetics that regulate major antioxidant pathways.
★ NF-κB pathway
★ Keap1-Nrf2-ARE pathway
★MAPK pathway
★PI3K/AKT/mTOR pathway
Advantages of Our Peptidomimetics
High Stability
High Antioxidant Activity
High Absorption
High Security
CD BioSciences focuses on developing peptidomimetics with anti-oxidant activity. As long as you provide the goal or direction you are interested in, our professional team will solve it immediately. Welcome to contact us for the best solution.
References
- Szeto, H. H. (2006). Cell-permeable, mitochondrial-targeted, peptide antioxidants. The AAPS Journal, 8(2), E277–E283.
- Broome, S. C., Woodhead, J. S. T., & Merry, T. L. (2018). Mitochondria-Targeted Antioxidants and Skeletal Muscle Function. Antioxidants, 7(8), 107.
All of our services are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
