CD BioSciences is a world-leading biotechnology company with state-of-the-art equipment and experienced staff. Our high-throughput peptidomimetic development platform can carry out a series of modifications to lead peptidomimetics according to the special needs of customers for structure and function to meet the needs of basic research, drug discovery and other related biochemical fields.
Significance of Peptidomimetic Modifications
The obtained lead peptidomimetics can overcome some structural and functional defects of natural peptides to a certain extent. However, due to the high requirements for the selectivity of action sites and the stability of finished drugs, it is of great significance to modify the lead peptidomimetics. It is foreseeable that the application of more modification strategies will greatly expand the chemical conformation library of the peptidomimetic itself, which is also of great significance to the expansion of the drug target library.
Our Services
CD BioSciences is dedicated to providing a variety of modification services for peptidomimetics.
Simple, nontoxic biotin-modified peptidomimetics can facilitate their delivery across cell membranes and increase oral uptake availability. Therefore, the biotinylated peptidomimetics have the potential to become drug lead compounds.
Cyclization-modified lead peptidomimetics are highly effective in improving in vivo stability and potency, especially for greater resistance to proteases. Furthermore, the limited conformational freedom leads to higher receptor selectivity and binding affinity by reducing unfavorable entropic effects.
Although local modification of peptidomimetics can cause conformational deviations, it is indeed one of the most effective strategies to induce extensive conformational changes to achieve desired results. Main and side chains are typically modified by single amino acid changes.
Peptidomimetics containing secondary structural motifs can effectively target protein-protein interaction interfaces. In addition, replacing the unstable corresponding structures of peptidomimetics with chemical fragments with similar protein secondary spatial structures is an effective strategy to obtain peptidomimetics with similar biological activities.
Our Service Processes
CD BioSciences specializes in providing various services for the development of peptidomimetics. The modification services we are committed to providing for peptidomimetics are not limited to the above. As long as you are interested in any aspect of peptidomimetic development, please contact us for the best solution.
All of our services are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
